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The Safety of Sweeteners

The Safety and efficacy of low and zero calorie sweeteners (LNCS) have been researched for decades. The U.S. Food and Drug Administration (FDA) regulates low-calorie sweeteners either through the Food Additive Approval Process or the Generally Recognized as Safe (GRAS) process1. Both processes follow established rigorous protocols and meet the FDA standard of safety1. Whether LNCS is evaluated as a Food Additive or GRAS ingredient, it is allowed for use by the entire population, including children, pregnant and lactating women, and people with diabetes.

Lack of Potential Carcinogenicity for Sucralose – Systematic Evaluation & Integration of Mechanistic Data Into the Totality of the Evidence

  • Systematic review and assessment of data related to the potential carcinogenicity of sucralose
  • Lack of activity for sucralose tested in various models and across mechanistic endpoints organized by Key Characteristics of Carcinogens, coupled with the lack of carcinogenicity in standard two-year cancer bioassays in rodents, reinforces regulatory conclusions that sucralose does not present a carcinogenic hazard to humans.
  • Findings support prior conclusions that sucralose is unlikely to be carcinogenic in humans

Chappell, GA. (2019). Food and Chemical Toxicology; DOI: 10.1016/j.fct.2019.110898

Estimation of Exposures to Non-nutritive Sweeteners (NNS) from Consumption of Tabletop Sweetener Products: A Review

  • Data suggest that using upper percentile consumption figures for powdered forms of NNS is a critical factor in intake estimations and may be a more realistic method by which overall exposure estimates could be obtained
  • When estimates are based on maximum concentration levels in powdered tabletop sweetener products, and 95th percentile consumption figures for tabletop sweetener products, intakes are below ADI values for all age groups.

Tennant, DR. (2018). Food Additives & Contaminants. Part A, 36:3, 359-365. DOI: 10.1080/19440049.2019.1566784.

Assessing the in Vivo Data on Low/Zero Calorie Sweeteners (LNCS) & the Gut Microbiota

  • Literature review found no credible evidence that reveals LNCS adversely affects health through an effect on the gut microbiome; rather, clear evidence shows dietary changes unrelated to LNCS consumption are likely major determinants of change in gut microbiota number and phyla

Lobach, AR, et. al. (2019). Food and Chemical Toxicology; 124:385-399. DOI: 10.1016/j.fct.2018.12.005

1 Roberts, A. (2016). The safety and regulatory process for low-calorie sweeteners in the United States. Physiology & Behavior. 164, Part B, 439-444.