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LNCS Help with Diabetes & Weight Management

Recommending zero calorie Splenda can help patients achieve and sustain their health goals. Switching from caloric sweeteners, like sugar, to Splenda helps your patients lose weight,1,2 manage diabetes and blood sugar levels,2 and live a healthier lifestyle.

Association of Low- and No-Calorie Sweetened Beverages as a Replacement for Sugar-Sweetened Beverages With Body Weight and Cardiometabolic Risk: A Systematic Review and Meta-analysis

  • 17 RCTs with 24 trial comparisons involving 1,733 adults with overweight or obesity who were at risk for or had diabetes.
  • Substitution of LNCSBs for SSBs was associated with reduced body weight, percentage of body fat and intrahepatocellular lipid.
  • The authors concluded that this systematic review and meta-analysis found that using LNCSBs as an intended substitute for SSBs was associated with small improvements in body weight and cardiometabolic risk factors without evidence of harm and had a similar direction of benefit as water substitution. The evidence supports the use of LNCSBs as an alternative replacement strategy for SSBs over the moderate term in adults with overweight or obesity who are at risk for or have diabetes.

McGlynn ND, et al. (2022). JAMA Netw Open. 2022;5(3):e222092. doi:10.1001/jamanetworkopen.2022.2092

Effects of Non Nutritive Sweeteners on Body Weight and BMI in Diverse Clinical Contexts: Systematic Review and Meta-analysis

  • 20 RCTs with a duration of at least 4 weeks were eligible,
    leading in 31 interventions/ comparisons, and a total population of n = 2914.
  • Participants consuming NNS showed statistically significant weight loss (-1.27kg; 17 studies) and BMI reduction
    (-0.08kg/m2; 3 studies) favoring NNS compared with non-users.   
  • Authors conclude these data suggest that replacing sugar with NNS leads to clinically appreciable lower body weight/ BMI values, especially in adults, people with overweight/ obesity,
    and in those under an unrestricted diet.
  • There is no evidence suggesting that NNS consumption promotes body weight gain.

Laviada-Molina, H., et. al. (2020). Obesity Reviews;1–13. DOI: 10.1111/obr.13020

A Randomized Control Trial Contrasting the Effects of 4 Low-calorie Sweeteners & Sucrose on Body Weight in Adults with Overweight or Obesity

  • Participants consumed 1.25-1.75L of beverage sweetened with sucrose, aspartame, saccharin, sucralose, or reb A daily for 12 weeks.
  • Of 123 subjects, reduction in body weight compared with other NNS at week 12 was significant (weight difference ≥ 1.37 ± 0.52 kg, P ≤ 0.008).
  • Energy intake decreased with sucralose consumption (P = 0.02).
  • Glucose tolerance was not significantly affected by any of the sweetener treatments.

Higgins, K, et. al. (2019). American Journal of Clinical Nutrition. 2019; 109:1288-1301. DOI: 10.1093/ajcn/nqy381

1 When used in place of sugar; Rogers PJ, Hogenkamp PS, de Graaf C, et al. (2016) Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies. Int J of Obes 40(3), 381-394. 2 Johnston C, Stevens B, Foreyt J et al. (2013) The Role of Low-calorie Sweeteners in Diabetes. Eur Endocrinology 9(2); 96-98.