The Safety of Sweeteners

The Safety and efficacy of low and zero calorie sweeteners (LNCS) have been researched for decades. The U.S. Food and Drug Administration (FDA) regulates low-calorie sweeteners either through the Food Additive Approval Process or the Generally Recognized as Safe (GRAS) process1. Both processes follow established rigorous protocols and meet the FDA standard of safety¹. Whether LNCS is evaluated as a Food Additive or GRAS ingredient, it is allowed for use by the entire population, including children, pregnant and lactating women, and people with diabetes.

Lack of Potential Carcinogenicity for Sucralose – Systematic Evaluation & Integration of Mechanistic Data Into the Totality of the Evidence

• Systematic review and assessment of data related to the potential carcinogenicity of sucralose
• Lack of activity for sucralose tested in various models and across mechanistic endpoints organized by Key Characteristics of Carcinogens, coupled with the lack of carcinogenicity in standard two-year cancer bioassays in rodents, reinforces regulatory conclusions that sucralose does not present a carcinogenic hazard to humans.
• Findings support prior conclusions that sucralose is unlikely to be carcinogenic in humans

Chappell, GA. (2019). Food and Chemical Toxicology; DOI: 10.1016/j.fct.2019.110898

Estimation of Exposures to Non-nutritive Sweeteners (NNS) from Consumption of Tabletop Sweetener Products: A Review

• Data suggest that using upper percentile consumption figures for powdered forms of NNS is a critical factor in intake estimations and may be a more realistic method by which overall exposure estimates could be obtained
• When estimates are based on maximum concentration levels in powdered tabletop sweetener products, and 95^th percentile consumption figures for tabletop sweetener products, intakes are below ADI values for all age groups.

Tennant, DR. (2018). Food Additives & Contaminants. Part A, 36:3, 359-365. DOI: 10.1080/19440049.2019.1566784.

Assessing the in Vivo Data on Low/Zero Calorie Sweeteners (LNCS) & the Gut Microbiota

• Literature review found no credible evidence that reveals LNCS adversely affects health through an effect on the gut microbiome; rather, clear evidence shows dietary changes unrelated to LNCS consumption are likely major determinants of change in gut microbiota number and phyla

Lobach, AR, et. al. (2019). Food and Chemical Toxicology; 124:385-399. DOI: 10.1016/j.fct.2018.12.005