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NACE Product Theater References

REFERENCES

A Closer Look at Low- and No-Calorie Sweeteners: Safety, Efficacy, and Implementation
Presenter: Neil Skolnik, MD
June 10, 2023

  1. Hales CM, Carroll MD, Fryar CD, Ogden CL. Prevalence of Obesity and Severe Obesity Among Adults: United States, 2017-2018. NCHS Data Brief. 2020;(360):1-8.
  2. Centers for Disease Control and Prevention. National Diabetes Statistics Report. Updated June 29, 2022. Accessed March 31, 2023. https://www.cdc.gov/diabetes/data/statistics-report/index.html
  3. U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary Guidelines for Americans, 2020-2025. 9th Edition. December 2020. Available at DietaryGuidelines.gov.
  4. Johnson RK, Lichtenstein AH, Anderson CAM, et al. Low-Calorie Sweetened Beverages and Cardiometabolic Health: A Science Advisory From the American Heart Association. Circulation. 2018;138(9):e126-e140. doi:10.1161/CIR.0000000000000569
  5. Ludwig DS, Apovian CM, Aronne LJ, et al. Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models. Eur J Clin Nutr. 2022;76(9):1209-1221.
    doi:10.1038/s41430-022-01179-2
  6. Huang Y, Chen Z, Chen B, et al. Dietary sugar consumption and health: Umbrella review. BMJ. 2023;381:e071609. Published 2023 Apr 5. doi:10.1136/bmj-2022-071609
  7. Bowman SA, Clemens JC, Martin CL, Anand J, Steinfeldt LC, and Moshfegh AJ. Added Sugars Intake of Americans: What We Eat in America, NHANES 2013-2014. Food Surveys Research Group. Dietary Data Brief No. 18. May 2017.
  8. High-Intensity Sweeteners. U.S. Food and Drug Administration. Updated December 19, 2017. Accessed March 29, 2023. https://www.fda.gov/food/food-additives-petitions/high-intensity-sweeteners
  9. Additional Information About High-Intensity Sweeteners Permitted For Use in Food in the United States. U.S. Food and Drug Administration. Updated February 8, 2018. Accessed March 29, 2023.
    https://www.fda.gov/food/food-additives-petitions/additional-information-about-high-intensity-sweeteners-permitted-use-food-united-states
  10. Shwide-Slavin C, Swift C, Ross T. Nonnutritive Sweeteners: Where Are We Today? Diabetes Spectrum. 2012;25(2):104-110. doi:https://doi.org/10.2337/diaspect.25.2.104
  11. National Cancer Institute. Artificial Sweeteners and Cancer. National Cancer Institute. Published 2013. https://www.cancer.gov/about-cancer/causes-prevention/risk/diet/artificial-sweetenersfact-sheet
  12. NTP (National Toxicology Program). 2021. Report on Carcinogens, Fifteenth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc15 (EndNote XML)
    DOI: https://doi.org/10.22427/NTP-OTHER-1003
  13. Nichol AD, Holle MJ, An R. Glycemic impact of non-nutritive sweeteners: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2018;72(6):796-804.
    doi:10.1038/s41430-018-0170-6
  14. Imamura F, O’Connor L, Ye Z, et al. Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, metaanalysis, and estimation of population attributable fraction. BMJ. 2015;351:h3576. Published 2015 Jul 21. doi:10.1136/bmj.h3576
  15. Pan A, Malik VS, Schulze MB, Manson JE, Willett WC, Hu FB. Plain-water intake and risk of type 2
    diabetes in young and middle-aged women. Am J Clin Nutr. 2012;95(6):1454-1460.
    doi:10.3945/ajcn.111.032698
  16. ElSayed NA, Aleppo G, Aroda VR, et al. 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes: Standards of Care in Diabetes-2023. Diabetes Care. 2023;46(Supple 1):S68-S96. doi:10.2337/dc23-S005
  17. Gardner C, Wylie-Rosett J, Gidding SS, et al. Nonnutritive sweeteners: current use and health perspectives: a scientific statement from the American Heart Association and the American Diabetes Association. Diabetes Care. 2012;35(8):1798 1808. doi:10.2337/dc12-9002
  18. Ruiz-Ojeda FJ, Plaza-Díaz J, Sáez-Lara MJ, Gil A. Effects of Sweeteners on the Gut Microbiota: A Review of Experimental Studies and Clinical Trials [published correction appears in Adv Nutr. 2020 Mar 1;11(2):468]. Adv Nutr. 2019;10(suppl_1):S31-S48. doi:10.1093/advances/nmy037
  19. Miller PE, Perez V. Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohort studies. Am J Clin Nutr. 2014;100(3):765- 777. doi:10.3945/ajcn.113.082826
  20. de Ruyter JC, Olthof MR, Seidell JC, Katan MB. A trial of sugar-free or sugar-sweetened beverages and body weight in children. N Engl J Med. 2012;367(15):1397-1406. doi:10.1056/NEJMoa1203034
  21. Laviada-Molina H, Molina-Segui F, Pérez-Gaxiola G, et al. Effects of nonnutritive sweeteners on body weight and BMI in diverse clinical contexts: Systematic review and meta-analysis. Obes Rev. 2020;21(7):e13020. doi:10.1111/obr.13020
  22. Maersk M, Belza A, Stødkilde-Jørgensen H, et al. Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study. Am J Clin Nutr. 2012;95(2):283-289. doi:10.3945/ajcn.111.022533
  23. Campos V, Despland C, Brandejsky V, et al. Sugar- and artificially sweetened beverages and intrahepatic fat: A randomized controlled trial. Obesity (Silver Spring). 2015;23(12):2335-2339.
    doi:10.1002/oby.21310
  24. Fitch C, Keim KS; Academy of Nutrition and Dietetics. Position of the Academy of Nutrition and Dietetics: use of nutritive and nonnutritive sweeteners [published correction appears in J Acad Nutr Diet. 2012 Aug;112(8):1279]. J Acad Nutr Diet. 2012;112(5):739-758. doi:10.1016/j.jand.2012.03.009
  25. MacLeod J, Franz MJ, Handu D, et al. Academy of Nutrition and Dietetics Nutrition Practice Guideline for Type 1 and Type 2 Diabetes in Adults: Nutrition Intervention Evidence Reviews and Recommendations. J Acad Nutr Diet. 2017;117(10):1637-1658. doi:10.1016/j.jand.2017.03.023
  26. Evert AB, Dennison M, Gardner CD, et al. Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report. Diabetes Care. 2019;42(5):731-754. doi:https://doi.org/10.2337/dci19-0014
  27. Use of non-sugar sweeteners: WHO guideline. Geneva: World Health Organization; 2023. Licence: CC BY-NC-SA 3.0 IGO.
  28. Rios-Leyvraz M, Montez J. Health effects of the use of non-sugar sweeteners: a systematic review
    and meta-analysis. Geneva: World Health Organization; 2022. Licence: CC BY-NC-SA 3.0 IGO.
  29. Bull FC, Al-Ansari SS, Biddle S, et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med. 2020;54(24):1451-1462. doi:10.1136/bjsports-2020-102955
  30. Center for Food Safety and Applied Nutrition. Changes to the nutrition facts label. U.S. Food and Drug Administration. Updated March 7, 2022. https://www.fda.gov/food/food-labeling-nutrition/changes-nutrition-facts-label